1.

Chicago Fire
 vs. Philadelphia Union

March 24, 2012
Saturday, 7:30 pm

 2.

Chicago Fire
 vs. Houston Dynamo

April 15, 2012
Sunday, 6:00 pm

 3.

Chicago Fire
 vs. Seattle Sounders FC

April 28, 2012
Saturday, 7:30 pm

 4.

Chicago Fire
 vs. Real Salt Lake

May 9, 2012
Wednesday, 7:30 pm

 5.

Chicago Fire
 vs. Sporting Kansas City

May 12, 2012
Saturday, 7:30 pm

 6.

Chicago Fire
 vs. FC Dallas

May 23, 2012
Wednesday, 7:30 pm

 7.

Chicago Fire
 vs. New York Red Bulls

June 17, 2012
Sunday, 4:00 pm

 8.

Chicago Fire
 vs. Columbus Crew

June 23, 2012
Saturday, 7:30 pm

 9.

Chicago Fire
 vs. Los Angeles Galaxy

July 8, 2012
Sunday, 2:00 pm

 10.

Chicago Fire
 vs. Vancouver Whitecaps

July 14, 2012
Saturday, 7:30 pm

 11.

Chicago Fire
 vs. Toronto FC

August 4, 2012
Saturday, 7:30 pm

 12.

Chicago Fire
 vs. New England Revolution

August 18, 2012
Saturday, 7:30 pm

 13.

Chicago Fire
 vs. Houston Dynamo

September 2, 2012
Sunday, 6:00 pm

 14.

Chicago Fire
 vs. Montreal Impact

September 15, 2012
Saturday, 7:30 pm

 15.

Chicago Fire
 vs. Columbus Crew

September 22, 2012
Saturday, 7:30 pm

 16.

Chicago Fire
 vs. Philadelphia Union

October 3, 2012
Wednesday, 7:30 pm

 17.

Chicago Fire
 vs. DC United

October 27, 2012
Saturday, 3:00 pm