1.

Houston Dynamo
 vs. DC United

May 12, 2012
Saturday, 3:30 pm

 2.

Houston Dynamo
 vs. Portland Timbers

May 15, 2012
Tuesday, 7:30 pm

 3.

Houston Dynamo
 vs. Los Angeles Galaxy

May 26, 2012
Saturday, 1:30 pm

 4.

Houston Dynamo
 vs. FC Dallas

June 16, 2012
Saturday, 4:00 pm

 5.

Houston Dynamo
 vs. Toronto FC

June 20, 2012
Wednesday, 8:00 pm

 6.

Houston Dynamo
 vs. Philadelphia Union

June 30, 2012
Saturday, 7:30 pm

 7.

Houston Dynamo
 vs. Chicago Fire

July 3, 2012
Tuesday, 7:30 pm

 8.

Houston Dynamo
 vs. DC United

July 15, 2012
Sunday, 8:00 pm

 9.

Houston Dynamo
 vs. Sporting Kansas City

July 18, 2012
Wednesday, 7:30 pm

 10.

Houston Dynamo
 vs. Houston Dynamo

July 21, 2012
Saturday, 7:30 pm

 11.

Houston Dynamo
 vs. New York Red Bulls

August 3, 2012
Friday, 7:00 pm

 12.

Houston Dynamo
 vs. Columbus Crew

August 19, 2012
Sunday, 8:00 pm

 13.

Houston Dynamo
 vs. Toronto FC

August 25, 2012
Saturday, 7:30 pm

 14.

Houston Dynamo
 vs. Real Salt Lake

September 6, 2012
Thursday, 7:30 pm

 15.

Houston Dynamo
 vs. New England Revolution

September 29, 2012
Saturday, 7:30 pm

 16.

Houston Dynamo
 vs. Montreal Impact

October 6, 2012
Saturday, 7:30 pm

 17.

Houston Dynamo
 vs. Philadelphia Union

October 20, 2012
Saturday, 6:30 pm